The "Three Columns" for Treating Problems in Optimum Structural Design -- Methods of Mathematical Optimization -- Multidisciplinary Optimization for Engineering Systems: Achievements and Potential -- Optimization of Axially Compressed Fiber Composite Cylindrical Shells -- Structural Optimization of Aircraft -- Evolution Strategy: Nature's Way of Optimization -- Computer Aided Protein Design: Methods and Applications -- The Quest for the Best. On the Responsibility of Scientists and Engineers.