1 Effects of Drugs on Energy Metabolism of the Brain and on Cerebral Transport -- 1. Introduction -- 2. Drugs and Brain Cell Energetics -- 3. Neurotropic Drugs Affecting Electron and Energy Transfer -- 4. Drugs and Brain Cell Permeabilities -- 5. Drugs Affecting Cerebral Biogenic Amine Levels -- 6. Ethanol -- 7. References -- 2 Role of Cyclic Nucleotides in the Nervous System -- 1. Introduction -- 2. Enzymatic Formation, Degradation, and Action of Cyclic Nucleotides -- 3. Accumulation of Cyclic Nucleotides -- 4. Functional Roles of Cyclic Nucleotides -- 5. Conclusion -- 6. References -- 3 Purinergic Transmission -- 1. Introduction -- 2. Distribution of Purinergic Nerves -- 3. Fine Structure and Histochemistry of Purinergic Nerves -- 4. Electrophysiology of Purinergic Transmission -- 5. Physiological Roles of Purinergic Nerves -- 6. Evidence that ATP is the Purinergic Nerve Transmitter -- 7. Pharmacology of Adenyl Compounds and Purinergic Transmission -- 8. Speculations on the Evolution and Development of Purinergic Nerves -- 9. Summary -- 10. References -- 4 Hypothalamic Hypophysiotropic Hormones -- 1. Introduction -- 2. Hypophysiotropic Hormone Action -- 3. Thyrotropin Releasing Factor (TRF) -- 4. Luteinizing Hormone Releasing Factor (LRF) -- 5. Corticotropin Releasing Factor (CRF) -- 6. Prolactin Release Inhibiting Factor (PIF) -- 7. Growth Hormone Releasing Factor (GRF) -- 8. Somatostatin-Somatotropin Release Inhibiting Factor (SRIF) -- 9. References -- 5 Binding, Metabolism, and Action of Steroid Hormones in the Central Nervous System -- 1. Introduction -- 2. Estrogens -- 3. Androgens -- 4. Glucocorticoids -- 5. Progestins -- 6. Conclusion -- 7. References -- 6 Opiate Receptor Mechanisms -- 1. Introduction -- 2. Biochemical Identification of Opiate-Receptor Binding -- 3. Localization of the Opiate Receptor to Synaptic Membranes -- 4. Regional Distribution of Opiate-Receptor Binding -- 5. Effect of Destruction of Norepinephrine, Serotonin, Acetylcholine, and Dopamine Tracts on Opiate-Receptor Binding -- 6. Phylogenetic Distribution of the Opiate Receptor -- 7. Effect of Sodium on Opiate-Receptor Binding -- 8. Toward a Theory of Addiction -- 9. References -- Addendum to Chapter 2.