In vivo production of thiopeptide variants / Feifei Zhang and Wendy L. Kelly -- Microviridin biosynthesis / Thomas K. Hemscheidt -- Cyclotide isolation and characterization / David J. Craik, Sonia Troeira Henriques, Joshua S. Mylne, and Conan K. Wang -- Ribosomally encoded cyclic peptide toxins from mushrooms / Jonathan D. Walton, Hong Luo, and Heather Hallen-Adams -- The Pictet-Spengler mechanism involved in the biosynthesis of tetrahydroisoquinoline antitumor antibiotics: a novel function for a nonribosomal peptide synthetase / Kento Koketsu [and others] -- Discovery and biosynthesis of phosphonate and phosphinate natural products / Spencer C. Peck, Jiangtao Gao, and Wilfred A van der Donk -- RlmN and AtsB as models for the overproduction and characterization of radical SAM proteins / Nicholas D. Lanz [and others] -- Fe(II)-dependent, uridine-5'-monophosphate [alpha]-ketoglutarate dioxygenases in the synthesis of 5'-modified nucleosides / Zhaoyong Yang, Jason Unrine, Koichi Nonaka, and Steven G. Van Lanen.

Tailoring reactions catalyzed by heme-dependent enzymes: spectroscopic characterization of the L-tryptophan-nitrating cytochrome P450 TxtE / Sarah M. Barry and Gregory L. Challis -- Oxidative tailoring reactions: catalyzed by nonheme iron-dependent enzymes: streptorubin B biosynthesis as an example / Paulina K. Sydor and Gregory L. Challis -- The rare fluorinated natural products and biotechnological prospects for fluorine enzymology / K.K. Jason Chan and David O'Hagan -- Enzymatic chlorination and bromination / Karl-Heinz van Pée -- Prenyltransferases of the dimethylallyltryptophan synthase superfamily / Xia Yu and Shu-Ming Li -- Serine carboxypeptidase-like acyltransferases from plants / Sam T. Mugford and Carsten Milkowski -- 4-methylideneimidazole-5-one-containing aminomutases in enediyne biosynthesis / Jeremy R. Lohman and Ben Shen -- Tailoring enzymes acting on carrier protein-tethered substrates in natural product biosynthesis / Shuangjun Lin, Tingting Huang, and Ben Shen -- High-throughput colorimetric assays for nucleotide sugar formation and glycosyl transfer / Richard W. Gantt and Jon S. Thorson.