Front Cover; International Review of Cell and Molecular Biology; International Review of Cell and Molecular Biology; International Review of Cell and Molecular BiologyEdited by KWANG W. JEONDepartment of Biochemistry University of TennesseeK ... ; Copyright ; Contents; Contributors; How Rab Proteins Determine Golgi Structure; 1. Introduction; 2. Rab Proteins and Their Subfamilies; 3. Golgi Apparatus and Its Organization; 4. Two Major Functional/Phenotypic Classes of Rab Proteins Based on Their Effects on Golgi Ribbon Organization.

5. Mechanistic Effect of Rab Proteins on Golgi Ribbon Organization5.1 General Mechanistic Predictions; 5.2 Rab6 and the Role of Individual Effectors; 5.3 Role of Rab33b in Rab6-Dependent Golgi Ribbon Organization; 5.4 Opposing Effects of Rab41 and Rab6 on Golgi Ribbon Organization; 6. Conclusions and Perspectives; Acknowledgments; References; Amyotrophic Lateral Sclerosis as a Spatiotemporal Mislocalization Disease: Location, Location, Location; 1. Introduction; 2. Amyotrophic Lateral Sclerosis; 2.1 Models for ALS Research; 3. Axonal Transport; 3.1 Axonal Cytoskeleton; 3.2 Motor Proteins.

3.3 Mitochondrial Transport4. RNA-Binding Proteins; 4.1 Tar DNA-Binding Protein 43; 4.2 Fused in Sarcoma; 4.3 MicroRNA and RBP; 4.4 Chromosome 9 Open Reading Frame 72; 5. Neurotrophic Factors and Their Precursor Forms; 6. Death Signals; 6.1 p75 Neurotrophin Receptor; 6.2 Death Receptor 6; 6.3 Fas; 6.4 Semaphorins; 7. Amyloid Precursor Protein; 8. Concluding Remarks; Acknowledgments; References; Malleable Mitochondrion of Trypanosoma brucei; 1. Introduction; 2. Maintenance and Expression of Genetic Information; 2.1 kDNA Replication and Maintenance; 2.2 Mitochondrial RNA Metabolism.

2.2.1 Transcription2.2.2 RNA processing; 2.2.3 RNA editing; 2.2.4 RNA turnover; 2.2.5 Mitochondrial tRNA import and modifications; 2.3 Translation and Ribosomes; 3. Mitochondrial Import; 3.1 Protein Import and Processing; 3.2 Transport of Metabolites; 3.3 Transport of Ions; 4. Mitochondrial Metabolism; 4.1 Carbohydrate Metabolism-Krebs Cycle; 4.2 Oxidative Phosphorylation; 4.3 Fatty Acid Biosynthesis; 4.4 Metabolism of Amino Acids; 4.5 Metabolism of Cofactors; 4.5.1 Heme metabolism; 4.5.2 Fe-S cluster and protein biogenesis; 5. Structural Proteins and Fission; 6. Concluding Remarks.

AcknowledgmentsReferences; Heredity and Self-Organization: Partners in the Generation and Evolution of Phenotypes; 1. Introduction; 2. Self-Organization in Biology; 2.1 Genes versus Cell Numbers; 2.2 Molecular Self-Organization and DNA; 2.3 Mechanical Forces and Self-Organization; 2.4 Self-Organization of Complex Biological Structures; 2.5 Dynamics; 2.6 Functional Plasticity May Be Based on Self-Organized Processes at Different Biological Scales; 2.7 Dynamics: Self-Organized Component of Developmental Robustness; 3. Internal Descriptions, Developmental Limitations and Buffering Variation.