Cover ; Title page; Copyright Page; Contents; Contributors ; Chapter One -- Evolution, Regulation, and Function of N-terminal Variable Region of Troponin T: Modulation of Muscle Contractility and Beyond ; Abstract; 1 Introduction ; 2 Molecular Structure of Troponin T ; 3 Evolution of Troponin T Isoform Genes ; 4 Alternative Splicing ; 5 Developmental Regulations ; 6 Posttranslational Modifications ; 6.1 Phosphorylation ; 6.2 Restrictive Proteolysis ; 7 Conclusion and Perspectives ; Acknowledgments; References; Chapter Two -- Phosphatidylethanolamine Metabolism in Health and Disease ; Abstract.

1 Introduction2 Heterogeneity of Biological Membranes; 3 PE Biosynthesis and Metabolism; 3.1 ER Pathways; 3.1.1 Kennedy or CDP-Ethanolamine Pathway; 3.1.2 Acylation of Lyso-PE and Head Group Exchange; 3.2 Mitochondrial Phosphatidylserine Decarboxylase (Psd) Pathway; 3.2.1 Biogenesis of Phosphatidylserine Decarboxylase 1; 3.2.2 PS Synthesis; 3.2.3 PS Transport; 3.2.3.1 Into Mitochondria; 3.2.3.2 Within Mitochondria; 3.2.4 Fate of PE Produced by Psd1p; 3.3 PE as Precursor for Other Lipids and Substrate for Posttranslational Modifications ; 3.3.1 Methylation of PE to Form PC.

3.3.2 Phosphoethanolamine for GPI Anchor Formation4 Cellular and Molecular Functions of PE; 4.1 PE as a Determinant of Protein Topology; 4.2 Membrane Fusion; 4.3 PE in Mitochondrial Function; 4.3.1 Oxidative Phosphorylation; 4.3.2 Mitochondrial Protein Biogenesis and Activity; 4.3.3 Mitochondrial Fusion; 4.4 Autophagy; 5 PE and Diseases; 5.1 Alzheimer's Disease; 5.2 Parkinson's Disease; 5.3 The Balance of PE and PC in Liver Steatosis and Steatohepatitis; 5.4 Infectious Disease; 5.4.1 Pathogenic Prion Generation; 5.4.2 Candida Virulence; 6 Concluding Remarks; Acknowledgment; References.

Chapter Three -- Microtubule Dynamics in Neuronal Development, Plasticity, and Neurodegeneration Abstract; 1 Introduction ; 2 Microtubule Structure and Dynamics ; 2.1 Composition and Organization of Microtubules ; 2.2 Microtubule Dynamics ; 2.3 Endogenous Microtubule Modulators and Posttranslational Modifications of Tubulin ; 3 Microtubules in Axonogenesis and Neuronal Plasticity ; 3.1 Axonogenesis and Axonal Branch Formation ; 3.2 Microtubule Dynamics During Axonogenesis ; 3.3 Microtubule Dynamics in Mature Axons and During Neuronal Plasticity.

3.3.1 Assembly and Transport of Axonal Microtubules 3.3.2 Modulation of Axonal Microtubule Stability ; 3.3.3 Microtubules in Axon Initial Segment ; 3.3.4 Microtubule Dynamics During Branch Formation ; 3.4 Cytoskeletal Interactions in Axon Formation and Plasticity ; 4 Microtubule Dynamics in Dendrites ; 4.1 Dendritogenesis and Dendritic Arborization ; 4.2 Microtubules During Dendritogenesis and in Mature Dendrites ; 4.3 Assembly and Transport of Dendritic Microtubules ; 4.4 Regulation of Dendritic Arborization by Neuronal Activity ; 4.5 Structure and Function of Dendritic Spines.