Hsp90 in Cancer : Beyond the Usual Suspects
Başlık:
Hsp90 in Cancer : Beyond the Usual Suspects
ISBN:
9780128024836
9780128022900
Yayın Bilgileri:
Cambridge, MA : Academic Press is an imprint of Elsevier, 2016.
Fiziksel Tanımlama:
1 online resource (xv, 257 pages : illustrations (some color)).
Series:
Advances in cancer research ; 129
Advances in cancer research ; 129.
Contents:
Unusual suspects in the twilight zone between the Hsp90 interactome and carcinogenesis / Evangelia Vartholomaiou, Pablo C. Echeverría and Didier Picard -- Impact of posttranslational modifications on the anticancer activity of Hsp90 inhibitors / Mark R. Woodford, Diana Dunn, Jonelle B. Miller, Sami Jamal, Len Neckers and Mehdi Mollapour -- Anticancer inhibitors of Hsp90 function: beyond the usual suspects / Gaurav Garg, Anuj Khandelwal and Brian S. J. Blagg -- HSP90 in cancer: transcriptional roles in the nucleus / Stuart K. Calderwood and Len Neckers -- Hsp90 as a 'chaperone' of the epigenome: insights and opportunities for cancer therapy / Jennifer S. Isaacs -- Emerging roles of extracellular Hsp90 in cancer / Daniel Senh Wong and Daniel G. Jay -- GRP94/gp96 in cancer: biology, structure, immunology and drug development / Bill X Wu, Feng Hong, Yongliang Zhang, Ephraim Ansa-Addo and Zihai Li -- HSP90 and immune modulation in cancer / Michael W. Graner -- Hsp90: a global regulator of the genotype-to-phenotype map in cancers / Daniel Jarosz.
Abstract:
This title focuses on the multifunctional molecular chaperone Hsp90 which regulates the post-translational stability and function of a broad repertoire of client proteins and discusses some of the lesser-known aspects of how Hsp90 and its related family members enable oncogenic transformation and malignant progression. Hsp90 in Cancer: Beyond the Usual Suspects, the latest volume in the Advances in Cancer Research series, focuses on the multifunctional molecular chaperone Hsp90 which regulates the post-translational stability and function of a broad repertoire of client proteins and discusses some of the lesser-known aspects of how Hsp90 and its related family members enable oncogenic transformation and malignant progression.
Local Note:
Elsevier
Subject Term:
Elektronik Erişim:
Full Text Available From Elsevier e-Books
Dil:
English