Front Cover; Ion Channels as Therapeutic Targets, Part A; Copyright; Contents; Contributors; Preface; Chapter One: Proteostasis Maintenance of Cys-Loop Receptors; 1. Introduction; 2. Folding, Assembly, and Degradation of Cys-Loop Receptors in the ER; 2.1. Folding and Assembly of Cys-Loop Receptors; 2.2. ERAD of the Cys-Loop Receptors; 3. Trafficking of Cys-Loop Receptors from ER to Golgi and to Plasma Membrane; 4. Protein Quality Control of Cys-Loop Receptors on the Plasma Membrane; 4.1. Clustering; 4.2. Endocytosis; 5. Other Regulations of Cys-Loop Receptors

5.1. Lipid Involvement in Trafficking and Clustering5.2. Phosphorylation Signaling in the Biogenesis of the Receptors; 6. Disease and Therapy; References; Chapter Two: Harnessing the Flow of Excitation: TRP, Voltage-Gated Na+, and Voltage-Gated Ca2+ Channels in Contemporary M ... ; 1. Introduction; 1.1. Place of TRP, Nav, and Cav Channels in the Flow of Excitation in Neural Circuits; 2. TRP Channels; 2.1. Structure and Structural Varieties-Subfamilies of TRP Channels; 2.2. Regulation and Activation Mechanisms; 2.3. Therapeutic Potential of TRP Channels; 3. Voltage-Gated Na+ Channels

3.1. Structure3.2. Inactivation of Nav Channels; 3.3. Isoforms and Expression; 3.4. Regulation of Nav Channels; 3.5. Nav Channels as Therapeutic Targets; 3.5.1. Local Anesthetics; 3.5.2. Nav Blockers as Antiarrhythmic and Antianginal Drugs; 3.5.3. Nav Blockers in Neurological Disordes; 4. Voltage-Gated Ca2+ Channels; 4.1. Structure and Function; 4.2. Varieties and Expression; 4.2.1. Cav1 Channels; 4.2.2. Cav2 Channels; 4.2.3. Cav3 Channels; 4.3. Regulation; 4.4. Calcium Channels in Pharmacological Therapy; 4.4.1. L-Type Channel Blockers; 4.4.2. Blockers and Modulators of Cav2 Channels

5.5. Considerations on the Treatment of Channelopathies6. Harnessing the Flow of Excitation in Neural Circuits; 7. Conclusion and Perspectives; Acknowledgments; References; Chapter Three: Ion Channels in Neurological Disorders; 1. Introduction; 1.1. Intricacy of Ion Channels in Membrane Physiology; 1.2. Role of Ion Channels in the Brain Homeostasis; 1.3. Impact of Channels on Blood-Brain Barrier; 1.4. How Channels Affect Gap Junctions, Release of Ions, and Homeostasis?; 1.5. What Are the Different Channels That Cause Ion Disturbance in Neurological Disorders?; 2. Aberrant Channels in NDDs