Front Cover; Profiles of Drug Substances, Excipients, and Related Methodology; Copyright; Contents; Preface to Volume 41; Chapter One: Bupropion Hydrochloride; 1. Description; 1.1. Nomenclature; 1.1.1. Systematic Chemical Name; 1.1.2. Nonproprietary Names; 1.1.3. Proprietary Names; 1.2. Formula; 1.2.1. Empirical Formula, Molecular Weight, CAS Number; 1.2.2. Structural Formula; 1.2.3. Stereochemical Description; 1.3. Elemental Analysis; 1.4. Appearance (Smell, Documented Taste); 1.5. Uses and Applications; 2. Method of Preparation; 2.1. Synthesis; 3. Physical Properties

3.1. Dissociation Constant3.2. Solubility; 3.3. pH; 3.4. Partition Coefficient; 3.5. Hygroscopicity; 3.6. Crystallographic Properties; 3.6.1. Polymorphism; 3.6.2. Single-Crystal Structures; 3.6.3. XRPD Pattern; 3.7. Thermal Analysis; 3.7.1. Melting Behavior; 3.7.2. Differential Scanning Calorimetry and Thermogravimetric Analysis; 3.8. Spectroscopy; 3.8.1. Electronic Spectroscopy; 3.8.1.1. UV/VIS Spectroscopy; 3.8.2. Vibrational Spectroscopy; 3.8.2.1. NIR; 3.8.2.2. Fourier Transform IR; 3.8.2.3. Raman; 3.8.3. Nuclear Magnetic Resonance Spectrometry; 3.8.3.1. 1H; 3.8.3.2. COSY; 3.8.3.3. NOESY

3.8.3.4. 13C3.8.3.5. HSQC; 3.8.3.6. HMBC; 3.8.3.7. DEPT; 3.8.3.8. 13C Solid-State; 3.8.4. Mass Spectrum; 4. Methods of Analysis; 4.1. Electrochemical Analysis; 4.2. Chromatographic Analysis; 4.2.1. Thin Layer Chromatography; 4.2.2. Gas Chromatography; 4.2.3. High-Performance Liquid Chromatography; 4.2.4. Ultra Performance Liquid Chromatography; 5. Stability; 5.1. Solution Stability; 5.2. Solid-State Stability; 5.3. Stability in Biological Medium; 6. Biological Properties; 6.1. Toxicity; 6.2. Drug Metabolism and Pharmacokinetics; 6.2.1. Absorption; 6.2.2. Distribution; 6.2.3. Metabolism

6.2.4. EliminationAcknowledgments; References; Chapter Two: Calcium Carbonate; 1. Description; 1.1. Nomenclature; 1.1.1. Systematic Chemical Names; 1.1.2. Nonproprietary Names; 1.1.3. Proprietary Names; 1.2. Formulae; 1.2.1. Empirical Formula, Molecular Weight, Identification Numbers; 1.2.2. Structural Formula; 1.3. Elemental Analysis; 1.4. Appearance; 2. Methods of Preparation; 2.1. Existence in Nature; 2.2. Preparation of Crystalline Form; 2.2.1. Calcium Acetate and Carbon Dioxide; 2.2.2. Calcium Hydroxide and Carbon Dioxide; 2.2.3. Calcium Chloride and Sodium Bicarbonate

2.2.4. Calcium Acetate and Ammonium Carbonate2.2.5. Calcium Chloride, Gelatin, and Urea; 2.2.6. Carbon Dioxide Sequestration; 2.2.7. Cockle Shell and Dodecyl Dimethyl Betaine; 2.2.8. Dolomite and Sucrose; 2.2.9. Quicklime or Hydrated Lime; 2.2.10. Wollastonite; 2.2.11. Dolomite; 2.2.12. Gypsum Waste; 2.3. Preparation of Amorphous Form; 2.3.1. Calcium Chloride and Sodium Carbonate; 2.3.2. Calcium Chloride and Dimethyl Carbonate; 2.3.3. Dolomitic Marble with the Aid of Poly(Acrylic Acid); 2.3.4. Calcium Hydroxide and Carbon Dioxide