Front Cover; Essays on Developmental Biology, Part A; Copyright; Contents; Contributors; Preface; Chapter One: Seeing is Believing, or How GFP Changed My Approach to Science; 1. From Fly Mutants to Developmental Control Genes; 2. From Mutants to Cell Behavior; 3. From Flies to Fish; 4. From GFP to GFP Binders; 5. The Crispr Revolution or Bringing It All Together; Acknowledgments; References; Chapter Two: The Notch-Mediated Proliferation Circuitry; 1. Notch Can Have Opposing Effects on Proliferation; 2. Notch Affects Proliferation in Both Cell-Autonomous and Non-Cell-Autonomous Manners

3. Notch and Proliferation in Oncogenesis4. Proliferative Effects of Notch in Stem Cells; 5. Notch Synergies in Proliferation; 6. A Notch-JNK Signaling Axis Couples Proliferation and Invasiveness; 7. Notch Synergies in Oncogenesis: A Hypothesis; References; Chapter Three: Defining the Path from Stem Cells to Differentiated Tissue; References; Chapter Four: Neuregulin/ErbB Signaling in Developmental Myelin Formation and Nerve Repair; 1. Introduction; 2. Schwann Cell Precursors; 3. Entry into the Myelination Program; 4. Nrg1 and Other Extrinsic Signals that Control Myelination

5. Proteolytic Processing is Rate Limiting for Nrg1 Activity and Function6. Rates of Protein Synthesis Control the End of Myelination and Myelin Thickness; 7. Nrg1 and Remyelination After Injury; Acknowledgments; References; Chapter Five: Oocyte Meiotic Spindle Assembly and Function; 1. Introduction; 2. Maintain Parity or Pare Down: Mitotic Versus Meiotic Cell Division; 3. Centrosomes: The Stars of Mitotic Spindle Poles; 4. The Curious Structure of (Some) Oocyte Meiotic Spindles: Acentriolar Poles; 5. The Curious Structure of Oocyte Meiotic Spindles, Part 2: Tiled Microtubules

6. Acentriolar Oocyte Meiotic Spindle Assembly: Microtubule Origins7. Acentriolar Oocyte Meiotic Spindle Assembly, Part 2: Pole Composition; 8. Acentriolar Oocyte Meiotic Spindle Assembly, Part 3: Pole Assembly; 9. Kinetochore Function and Pole Coalescence; 10. A Pushy View of Kinetochore Function and Chromosome Dynamics During Oocyte Meiosis; 11. An Alternative Model for Chromosome Movements in C. elegans Oocytes: Sides Matter; 12. Advancing Our Understanding of Oocyte Meiotic Spindle Assembly: Genetics and Live Cell Imaging; Acknowledgments; References

Chapter Six: Self-Organization of Spatial Patterning in Human Embryonic Stem Cells1. Introduction; 2. Self-Organization of Human Embryonic Germ Layers; 3. Self-Organization of Neural Rosettes; 4. Challenges and Future Directions; References; Chapter Seven: The Neural Crest Migrating into the Twenty-First Century; 1. Introduction; 2. A Brief History; 3. Neural Crest Migration; 4. Gene Regulatory Network Controlling Neural Crest Formation; 5. Differentiation of Neural Crest Cells into Multiple Lineages; 6. Evolution of the Neural Crest