Front Cover; Neuroscience for Addiction Medicine: From Prevention to Rehabilitation -- Constructs and Drugs; Copyright; Contributors; Contents; Preface: Neuroscience for Addiction Medicine: From Prevention to Rehabilitation: ; Reference; Part 1: Neuroscience Constructs for Addiction Medicine; Chapter 1: Neuroscience of resilience and vulnerability for addiction medicine: From genes to behavior; 1. Behavioral Traits; 2. Neurobiological Factors; 3. Genetics; 4. Epigenetics; 5. Developmental Factors; 6. Conclusion and Future Directions; References.

Chapter 2: Drug-induced neurotoxicity in addiction medicine: From prevention to harm reduction1. Introduction; 2. Drug-Induced Neurotoxicity: Mechanisms and Pathways; 2.1. Oxidative Stress; 2.2. Apoptotic Processes; 2.3. Excitotoxicity; 2.4. Involvement of Other Biochemical Mechanisms; 3. Drug-Induced Neurotoxicity: Triggering and Susceptibility Factors; 3.1. Drug-Related Factors; 3.1.1. Active metabolites and adulterants; 3.1.2. Polydrug abuse; 3.1.3. Substance withdrawal; 3.2. Environmental Factors; 3.2.1. Chronic stress; 3.2.2. Ambient temperature; 3.2.3. Diet and nutritional supplies.

3.3. Individual-Related Factors3.3.1. The role of age; 3.3.2. The role of gender; 3.3.3. Gestational drug exposure; 3.3.4. Antioxidant status; 4. Drug-Induced Neurotoxicity: Potential Preventive Strategies; 4.1. Modulating Brain Dopamine Levels; 4.2. Addressing Oxidative Challenge; 4.3. Antiapoptotic Approach; 4.4. NMDA Receptor Antagonism; 4.5. Rotation in Drugs; 4.6. Anti-Inflammatory Approach; 4.7. Thermoregulatory Interventions; 5. Drug-Induced Neurotoxicity in Addiction Medicine; 5.1. Treatment Seekers; 5.2. Nontreatment Seekers; 5.3. Relapse-Prone Patients.

5.4. Intoxicated Patients During Overdose or Binge Episodes5.5. Clients Suffering from Severe Drug Withdrawal Symptoms; 6. Conclusion and Future Directions; Acknowledgments; References; Chapter 3: Stress psychobiology in the context of addiction medicine: from drugs of abuse to behavioral addictions; 1. Introduction; 1.1. Definitions; 2. Stress Response Systems; 2.1. Sympathetic-Adrenal-Medullary Axis; 2.2. Hypothalamic-Pituitary-Adrenal Axis; 2.3. The Integration of the Stress Response; 2.4. Common Pathways Between Stress and Addiction.

3. Stress as a Vulnerability Factor for Initiation and Maintaining Substance Abuse3.1. Developmental Studies in Animals; 3.2. Developmental Studies in Humans; 4. Stress as a Risk Factor for Relapse; 5. Stress and Behavioral Addictions; 6. Moderators of the Stress Effects on the Addiction Cycle; 6.1. Sex; 6.2. Genetics; 7. Discussion; 8. Conclusion; References; Chapter 4: Reinforcement principles for addiction medicine; from recreational drug use to psychiatric disorder; 1. Introduction; 2. Positive and Negative Reinforcement; 3. Secondary and Conditioned Reinforcement.