Front Cover; Hematopoiesis; Copyright; Contents; Contributors; Preface; Chapter One: Regulation of Blood Stem Cell Development; 1. Introduction; 1.1. HSC Generation; 1.2. Tracking Hematopoietic Cell Generation from Embryonic Endothelium; 1.3. Regulation of Hemogenic Endothelium; 1.4. Hemogenic Transcriptional Program; 1.5. Reprogramming; References; Chapter Two: Hematopoietic Stem Cell and Its Bone Marrow Niche; 1. Introduction; 2. Evolution of the Stem Cell Niche Concept; 3. Location Matters; 4. Cellular Participants in the Bone Marrow Microenvironment; 4.1. Osteolineage Cells

4.2. Perivascular Cells4.3. Endothelial Cells; 4.4. Adipocytes; 4.5. Macrophages; 5. The Sympathetic Nervous System; 6. HSC Mobilization from the BM Niche; 7. Niche of Hematopoietic Malignancies; 8. Perspectives; References; Chapter Three: The Hematopoietic Stem and Progenitor Cell Cistrome: GATA Factor-Dependent cis-Regulatory Mechanisms; 1. cis-Regulatory Mechanisms; 2. GATA Factor Interactions with DNA and Chromatin; 2.1. Sequence Requirements; 2.2. Genomic and Bioinformatics Analysis; 2.3. Discovery and Validation of Enhancers Controlling HSPCs

3. Components of Scl/TAL1 and GATA Factor Complexes at E-box-GATA Elements3.1. LMO2; 3.2. LDB1; 3.3. KLF1; 3.4. SWI/SNF Chromatin-Remodeling Complex; 3.5. Single-Stranded DNA-Binding Proteins; 4. HSPC Cistrome; 5. Perspective; References; Chapter Four: ETS Transcription Factor ETV2/ER71/Etsrp in Hematopoietic and Vascular Development; 1. Introduction; 2. Etv2 Is Transiently Expressed in the Hemangiogenic Progenitors; 3. ETV2 Is Sufficient to Induce Hematopoietic and Endothelial Cell Formation; 4. Nonredundant and Transient Role of ETV2 in Hematopoietic and Endothelial Cell Formation

5. ETV2, VEGF, and FLK1 in Hematopoietic and Endothelial Cell Formation6. ETV2 Regulates Hemangiogenic versus Cardiac Mesoderm Outcome; 7. ETS Hierarchy and ETS Switching Mechanisms in Hematopoietic and Vascular Development; 8. ETV2 in Definitive Hematopoietic Program and Function; 9. Regulation of Etv2 Expression; 10. Closing Thoughts and Future Directions; Acknowledgments; References; Chapter Five: Taking the Leap: Runx1 in the Formation of Blood from Endothelium; 1. The Three Waves of Blood Cell Formation; 2. The Role of Runx1 in the Formation of Embryonic Progenitors and HSCs

3. The Temporal Requirement for Runx1 in Hemogenic Endothelium4. Downstream Runx1 Targets That Execute the Endothelial to Hematopoietic Cell Transition; 5. Epigenetic Regulation by Runx1; 6. Cis-Acting Sequences Regulating Runx1 Transcription; 7. The Gene Regulatory Network Upstream of Runx1; 8. Signaling Pathways Regulating Runx1 Expression in the Aorta; 8.1. Notch Signaling; 8.2. Fibroblast Growth Factor and Bone Morphogenic Protein Signaling; 9. Conclusions and Future Directions; References; Chapter Six: SCL/TAL1 in Hematopoiesis and Cellular Reprogramming; 1. Introduction