Klotho

Başlık:

Klotho

ISBN:

9780128052358

Edition:

First edition.

Yayın Bilgileri:

Cambridge, MA : Academic Press is an imprint of Elsevier, 2016.

Fiziksel Tanımlama:

1 online resource (xiv, 338 pages) : color illustrations.

Series:

Vitamins and hormones ; volume one hundred and one

Vitamins and hormones ; v. 101.

Contents:

1. Introduction2. The Components of the Signaling Complex; 2.1. Klotho-Beta; 2.1.1. The Klotho Family of Receptors; 2.1.2. KLB Structure; 2.1.3. KLB Tissue Expression; 2.2. Fibroblast Growth Factor Receptors; 2.2.1. The Fibroblast Growth Factor Receptor Family; 2.2.2. Fibroblast Growth Factor Receptor Structure; 2.2.3. FGFR1c Tissue Expression; 2.3. Endocrine FGF21; 2.3.1. The Fibroblast Growth Factor Family; 2.3.2. FGF Structure; 2.3.3. Endocrine FGF21 Structure; 2.3.4. Endocrine FGF21 Tissue Expression; 3. Specific Interactions Driving Complex Formation; 3.1. Interaction of FGF21 and KLB.

3.2. Interaction of FGF21 and FGFR13.3. Interaction of KLB and FGFR1; 3.4. KLB Domains Relevant for Binding; 4. Stoichiometry of the Signaling Complex; 4.1. Preformed KLB Heterodimers with FGFR1c/4; 5. Other Regulators of the Signaling Complex Formation; 5.1. KLB Inactivation by the Galectin Lattice; 5.2. ECM Regulation of FGFRs; 5.3. Fibroblast Growth Factor Receptor 5; 6. Summary; References; Chapter Three: Klotho-Dependent Cellular Transport Regulation; 1. Introduction; 1.1. Gene Structure and Klotho Protein Types; 1.2. Ectodomain Shedding and Some Functions Mediated by Klotho.

1.3. Transport Proteins in the Different Types of Plasma Membrane Transport Systems2. Klotho in the Regulation of Cellular Transport; 2.1. Klotho in the Regulation of Ion Channels; 2.2. Klotho in the Regulation of Carriers; 2.3. Klotho in the Regulation of Na+/K+-ATPase; 3. Conclusion and Future Directions; Acknowledgment; References; Chapter Four: Klotho and the Growth Hormone/Insulin-Like Growth Factor 1 Axis: Novel Insights into Complex Interactions; 1. The Pituitary Gland and the GH/IGF-1 Axis; 1.1. Regulation of GH Transcription and Secretion.

1.1.1. Hypothalamic Regulation of GH Secretion1.1.2. Peripheral Regulation of GH Secretion; 1.1.3. Autocrine and Paracrine Regulation of GH Secretion; 1.2. The Activities of GH and IGF-1; 2. Klotho: History, Structure, Functions; 3. Klotho as a Circulating Hormone; 3.1. Available Tests; 3.2. Factor Affecting Circulating Klotho Levels; 3.3. Regulation of Klotho Shedding; 4. Klotho and the Pituitary: Lessons from Mice and Humans; 5. Klotho Regulates GH Secretion; 5.1. Mechanisms of Klotho Activity on GH Secretion; 6. Klotho and the GH/IGF-1 Axis in Humans: Health and Disease States.

Abstract:

Klotho is the latest edition of a series first published in 1943 on Vitamins and Hormones and the longest-running serial published by Academic Press. It provides up-to-date information on vitamin and hormone research spanning data from molecular biology to the clinic, with volumes focusing on a single molecule or on a disease that is related to vitamins or hormones that are interpreted broadly so that related substances, such as transmitters, cytokines, growth factors, and others can be reviewed. Contains contributions from experts in the field of vitamins and hormonesCovers a vast array of subjectsIn-depth, current information at the molecular to clinical levels.

Local Note:

Elsevier

Subject Term:

Membrane proteins.

Enzymes.

Protéines membranaires.

enzyme.

SCIENCE -- Life Sciences -- Biochemistry.

Enzymes

Membrane proteins

Added Author:

Litwack, Gerald,