2.2.1. Posttranslational Acetylation2.2.2. Oxidation; 2.3. HMGB1-Receptor Families; 2.3.1. Receptor for Advanced Glycation End Products; 2.3.2. Toll-Like Receptors; 2.3.3. Recently Discovered HMGB1 Receptors; 3. HMGB1 in the Nucleus-An Architectural Factor; 3.1. Nucleolar Functions; 3.1.1. DNA Replication, Repair, and V(D)J Recombination; 3.1.2. Gene Transcription Transfer and Delivery; 3.1.3. Nucleosome Structure and Dynamics; 3.1.4. Telomere Homeostasis; 3.2. HMGB1 as a Damage Recognition Protein Mediating the Antitumor Effect of the Chemotherapeutic Drug cis-Platin

3.3. HMGB1 Protein-An Important Player in cis-platin-Based Therapy3.3.1. HMGB1 Affects the Repair of DNA Damaged by the Antitumor Drug cis-Platin In Vitro; 3.3.2. The Impact of HMGB1 Protein for the Repair Potential of Human Cancer Cell Lines: A Significant Issue for Therapeut ... ; 4. HMGB1 Outside the Cell; 4.1. HMGB1 as a Signaling Molecule; 4.2. HMGB1 and Diseases; 5. HMGB1 as a Therapeutic Target; 5.1. Antibody-Based Targeting; 5.2. Peptides and Protein Inhibitors of HMGB1; 5.3. Blockage of HMGB1-Receptor Signaling; 5.4. Small Molecules Inhibiting HMGB1