Front Cover; Neurotrophins; Copyright; Contents; Contributors; Preface; Chapter One: Crystal Structures of Neurotrophin Receptors Kinase Domain; 1. Introduction; 1.1. Trk Receptors Global Structure; 2. Crystal Structure of TrkA, TrkB, and TrkC Kinase Domain; 2.1. Trk Kinase Domain apo Structures; 2.2. Trk Kinase Domain Complexed Structures; 3. Pharmacological Approach: The Selectivity Issue; 4. Conclusion and Future Directions; Acknowledgments; References; Chapter Two: BDNF Propeptide: A Novel Modulator of Synaptic Plasticity; 1. Neurotrophins and Their Biological Actions

2. NT Receptors and Their Signaling3. Synthesis, Intracellular Trafficking, and Secretion of BDNF Protein; 4. Modulation of Synaptic Function by BDNF; 5. BDNF Prodomain: New Roles Beyond a Molecular Chaperone; 6. BDNF and Its Propeptide Are Localized in Presynaptic Dense Core Vesicles; 7. The BDNF Propeptide Is a Novel Synaptic Modulator; 8. Role of the Val66Met Polymorphism in BDNF Propeptide-Dependent LTD; 9. Discussion; References; Chapter Three: Zinc Interactions With Brain-Derived Neurotrophic Factor and Related Peptide Fragments; 1. Introduction; 2. Brain-Derived Neurotrophic Factor

2.1. Peptides-Mimicking BDNF3. Zinc in the Brain; 3.1. Zinc Metallostasis in the Brain; 4. Zinc(II) Interaction With BDNF and Related Peptides; 4.1. Peptide Delivery; 5. Zinc, BDNF, and Diet; 6. Conclusion; Acknowledgments; References; Chapter Four: Structural Characterization of the p75 Neurotrophin Receptor: A Stranger in the TNFR Superfamily; 1. TNFR Superfamily; 1.1. The p75 Neurotrophin Receptor; 2. Structural Characterization of p75NTR; 2.1. The Extracellular Domain (ECD); 2.1.1. p75ECD Interaction With Neurotrophins; 2.1.2. p75ECD Interaction With Pro-NGF

2.1.3. p75ECD Interaction With Sortilin3. The Transmembrane Domain (TMD); 4. The Intracellular Domain (ICD); 4.1. p75NTR Juxtamembrane Domain (JTM); 4.2. The p75NTR Death Domain (DD); 4.2.1. p75DD-p75DD Symmetric Complex; 4.2.2. p75-DD/p45-DD Interaction; 4.2.3. p75DD-RhoGDI Complex; 4.2.4. p75-DD/RIP2-CARD Complex; 5. Conclusions and Future Directions; Acknowledgments; References; Chapter Five: Releasing Mechanism of Neurotrophic Factors via Polysialic Acid; 1. Introduction; 2. Biochemical Features of BDNF; 3. Regions and Cellular Distribution of BDNF; 4. Extracellular Secretion of BDNF

4.1. BDNF Release via Exocytosis4.2. BDNF Release via Polysialic Acid; 5. Conclusion; Acknowledgments; References; Chapter Six: Emergent Role of Coronin-1a in Neuronal Signaling; 1. Introduction; 2. The Coronin Family of Proteins; 2.1. Type I Coronin Family; 2.2. Type II Coronins; 2.3. Type III Coronin; 3. Type I Coronins as Actin Regulators; 4. Coronin-1a as a Signaling Effector Protein; 4.1. Coronin-1a in Pathogen-Host Signaling; 4.2. Coronin-1a as a Regulator of Internalization Mechanisms; 4.3. Coronin-1a Is Required for GPCR Activation in Excitatory Neurons