The Role of Matrix Metalloproteinases in Development, Repair, and Destruction of the Lungs / Amanda Y. Hendrix and Farrah Kheradmand -- Matrix Metalloproteinases in Kidney Disease: Role in Pathogenesis and Potential as a Therapeutic Target / Alan R. Parrish -- Regulation of Matrix Metalloproteinase in the Pathogenesis of Diabetic Retinopathy / Renu A. Kowluru and Manish Mishra -- Matrix Metalloproteinases in Normal Pregnancy and Preeclampsia / Juanjuan Chen and Raouf A. Khalil -- Matrix Metalloproteinases, Neural Extracellular Matrix, and Central Nervous System Pathology / Ciro De Luca and Michele Papa -- Matrix Metalloproteinases in Bone Resorption, Remodeling, and Repair / Katiucia B.S. Paiva and José M. Granjeiro -- Matrix Metalloproteinases and Synovial Joint Pathology / Charles J. Malemud -- Metalloproteinases in Rheumatoid Arthritis: Potential Therapeutic Targets to Improve Current Therapies / Yoshifumi Itoh -- The Roles of Matrix Metalloproteinases in Pancreatic Cancer / Anna M. Knapinska, Christie-Anne Estrada and Gregg B. Fields -- Matrix Metalloproteinase Inhibitors as Investigational and Therapeutic Tools in Unrestrained Tissue Remodeling and Pathological Disorders / Jie Liu and Raouf A. Khalil.