Contributors -- Preface -- Mouse Neuroblastoma CB1 Cannabinoid Receptor-Stimulated [35S]GTPgammaS Binding: Total and Antibody-Targeted Galpha Protein-Specific Scintillation Proximity Asays / by Khalil Eldeeb, Sandra Leone-Kabler, Allyn C. Howlett -- Protocols and Good Operating Practices in the Study of Cannabinoid Receptors / by Linda M. Console-Bram, Pingwei Zhao, Mary E. Abood -- Real-Time Measurement of Cannabinoid Receptor-Mediated cAMP Signaling / by Morag R. Hunter, David B. Finlay, Christa E. Macdonald, Erin E. Cawston, Natasha L. Grimsey, Michelle Glass -- Techniques for the Cellular and Subcellular Localization of Endocannabinoid Receptors and Enzymes in the Mammalian Brain / by Luigia Cristino, Roberta Imperatore, Vincenzo Di Marzo -- Endocannabinoid Transport Proteins: Discovery of Tools to Study Sterol Carrier Protein-2 / by Cecilia J. Hillard, Huan Huang, Caleb D. Vogt, Beatriz E. Rodrigues, Terrence S. Neumann, Daniel S. Sem, Friedhelm Schroeder, Christopher W. Cunningham -- Lipidomics: A Corrective Lens for Enzyme Myopia / by Heather B. Bradshaw, Emma Leishman -- Functional Analysis of Mitochondrial CB1 Cannabinoid Receptors (mtCB1) in the Brain / by Su Melser, Antonio C. Pagano Zottola, Roman Serrat, Nagore Puente, Pedro Grandes, Giovanni Marsicano, Etienne Hebert-Chatelain -- Modeling Neurodegenerative Disorders for Developing Cannabinoid-Based Neuroprotective Therapies / by Javier Fernández-Ruiz, María Gómez-Ruiz, Concepción García, Mariluz Hernández, José A. Ramos -- Metabolic Profiling of CB1 Neutral Antagonists / by Herbert H. Seltzman, Rangan Maitra, Katharine Bortoff, Jay Henson, Patricia H. Reggio, Daniel Wesley, Joseph Tam -- Ligand-Assisted Protein Structure (LAPS): An Experimental Paradigm for Characterizing Cannabinoid-Receptor Ligand-Binding Domains / by David R. Janero, Anisha Korde, Alexandros Makriyannis -- New Methods for the Synthesis of Cannabidiol Derivatives / by Ana Lago-Fernandez, Vanessa Redondo, Laura Hernandez-Folgado, Laura Figuerola-Asencio, Nadine Jagerovic -- Approaches to Assess Biased Signaling at the CB1R Receptor / by Robert B. Laprairie, Edward L. Stahl, Laura M. Bohn -- Design and Synthesis of Cannabinoid 1 Receptor (CB1R) Allosteric Modulators: Drug Discovery Applications / by Abhijit R. Kulkarni, Sumanta Garai, David R. Janero, Ganesh A. Thakur -- Assessing Allosteric Modulation of CB1 at the Receptor and Cellular Levels / by Caitlin E. Scott, Debra A. Kendall -- Purification of Functional CB1 and Analysis by Site-Directed Fluorescence Labeling Methods / by Jonathan F. Fay, David L. Farrens -- Mass Spectrometry Analysis of Human CB2 Cannabinoid Receptor and Its Associated Proteins / by Zhao-Hui Song, Alyssa S. Laun, Jian Cai -- Expression and NMR Structural Studies of Isotopically Labeled Cannabinoid Receptor Type II / by Alexei Yeliseev, Klaus Gawrisch -- Methods for the Development of In Silico GPCR Models / by Paula Morales, Dow P. Hurst, Patricia H. Reggio -- Molecular Dynamics Methodologies for Probing Cannabinoid Ligand/Receptor Interaction / by Diane L. Lynch, Dow P. Hurst, Derek M. Shore, Mike C. Pitman, Patricia H. Reggio -- Author Index -- Subject Index.