Front Cover -- Selenium and Selenoproteins in Cancer -- Copyright -- Contents -- Contributors -- Preface -- Chapter One: The Epidemiology of Selenium and Human Cancer -- 1. Introduction -- 2. Selenium and Cancer: Scope of Research -- 3. Observational Studies -- 4. Randomized Controlled Trials -- 5. The Nutritional Prevention of Cancer Trial -- 6. The Selenium and Vitamin E Cancer Prevention Trial -- 7. The Other Trials -- 8. A Natural Experiment on Selenium and Cancer -- 9. Selenium in Cancer Therapy -- 10. Conclusion -- Acknowledgments -- References

Chapter Two: Selenoproteins in Tumorigenesis and Cancer Progression1. Introduction -- 2. Selenoprotein Production -- 3. Investigating Selenoproteins Through Sec tRNA Mutations -- 4. Role of Specific Selenoproteins in Tumorigenesis -- 4.1. Selenoprotein P -- 4.2. Glutathione Peroxidases -- 4.3. Thioredoxin Reductases -- 4.4. Selenoprotein F -- 5. Considerations and Conclusions -- Acknowledgments -- References -- Chapter Three: Selenoproteins and Metastasis -- 1. Introduction -- 2. Metastasis -- 2.1. Local Invasion -- 2.2. Intravasation

2.3. Survival in Vasculature, Extravasation, and Formation of Micrometastases3. Dietary Selenium and Selenium Supplementation -- 4. Thioredoxin Reductases and Redox Tone -- 5. GPX and ROS Regulation -- 6. Selenoproteins Involved in ER Stress and Calcium Flux -- 7. Other Potential Roles for Selenoproteins in Metastasis -- 8. Conclusions -- Acknowledgments -- References -- Chapter Four: Selenium-Dependent Glutathione Peroxidases During Tumor Development -- 1. Introduction -- 2. Expression Profile of Se-Dependent GPxes in Different Types of Tumors

3. Hydroperoxides and Redox Signaling During Cancer Development4. Impact of Individual GPxes on Tumor Development -- 4.1. GPx1 -- 4.1.1. Cell Death -- 4.1.2. Redox Signaling -- 4.1.3. Metabolism -- 4.2. GPx2 -- 4.2.1. Cell Death -- 4.2.2. Redox Signaling -- 4.3. GPx3 -- 4.3.1. Cell Death -- 4.3.2. Redox Signaling -- 4.4. GPx4 -- 4.4.1. Cell Death -- 4.4.2. Redox Signaling -- 5. Conclusions -- Acknowledgment -- References -- Chapter Five: Targeting the Selenoprotein Thioredoxin Reductase 1 for Anticancer Therapy -- 1. Introduction

1.1. The Thioredoxin System1.2. Thioredoxin Reductase 1 -- 2. TrxR1 as an Important Enzyme in Cancer -- 3. Conclusions -- Acknowledgments -- References -- Chapter Six: The Regulation of Pathways of Inflammation and Resolution in Immune Cells and Cancer Stem Cells by Selenium -- 1. Tumor Microenvironment: Interplay With Immune Cells and Pathways of Inflammation -- 2. Selenium-Dependent Effects on Cancer Stem Cells in Leukemia -- 3. Interaction of LSCs With Immune Cells Mediated by CyPGs -- 4. Targeting LSC Metabolism With Selenium -- 5. Summary -- Acknowledgments