Front Cover -- The Role of Neuropeptides in Addiction and Disorders of Excessive Consumption -- Copyright -- Contents -- Contributors -- Preface -- Chapter One: Neuropeptides and Addiction: An Introduction -- References -- Chapter Two: Corticotropin-Releasing Factor (CRF) and Addictive Behaviors -- 1. Introduction -- 2. CRF Stress Systems -- 3. CRF, the HPA Axis, and Addiction -- 4. Extrahypothalamic CRF Systems -- 5. Role for CRF-CRF1 Systems in Animal Models of Addiction -- 6. Central Extended Amygdala -- 6.1. Cellular Mechanisms of CRF

7. Ventral Tegmental Area8. Prefrontal Cortex -- 9. Compulsive Eating -- 10. Conclusion -- Acknowledgments -- References -- Chapter Three: Dynorphin/Kappa Opioid Receptor Signaling in Preclinical Models of Alcohol, Drug, and Food Addiction -- 1. Introduction -- 1.1. Stress, Addiction, and Kappa Opioid Receptors -- 1.2. Modulation of Neurotransmitter Signaling by Kappa Opioid Receptors -- 1.3. Kappa Opioid Receptors in the NAc -- 1.4. Kappa Opioid Receptors in the VTA -- 1.5. Measuring Dynorphin Levels -- 1.6. Opponent Process Theory of Addiction

1.7. Sex Differences in Kappa Opioid Receptor Function2. Ethanol and Kappa Opioid Receptors -- 2.1. Kappa Opioid Receptors and Ethanol Consumption -- 2.2. Kappa Opioid Receptors and Chronic Ethanol Exposure -- 2.3. Ethanol Effects on the Dynorphin/Kappa Opioid Receptor System -- 2.4. Ethanol, Kappa Opioid Receptors, and Dopamine -- 3. Cocaine and Kappa Opioid Receptors -- 3.1. Chronic Stress, Kappa Opioid Receptors, and Cocaine -- 3.2. Timing of Kappa Opioid Receptor Activation, Dopamine Deficits, and Cocaine Effects -- 3.3. Kappa Opioid Receptors and DATs

3.4. Cocaine, Kappa Opioid Receptors, and DATs3.5. Reinstatement of Cocaine Self-Administration -- 4. Obesity and Kappa Opioid Receptors -- 4.1. The Dynorphin/Kappa Opioid Receptor System and Hereditary Obesity -- 4.2. Dynorphin/Kappa Opioid Receptor System and Palatable Food Consumption -- 4.3. Dynorphin/Kappa Opioid Receptor System and Food Deprivation -- 5. Kappa Opioid Receptor-Based Therapeutics -- References -- Further Reading -- Chapter Four: The Role of the Ghrelin System in Drug Addiction -- 1. Introduction -- 2. Ghrelin and Alcohol

2.1. Preclinical Evidence2.2. Clinical Evidence -- 3. Ghrelin and Stimulants -- 3.1. Preclinical Evidence -- 3.2. Clinical Evidence -- 4. Ghrelin and Tobacco/Nicotine -- 4.1. Preclinical Evidence -- 4.2. Clinical Evidence -- 5. Ghrelin and Opioids -- 5.1. Preclinical Evidence -- 6. Ghrelin and Cannabis -- 6.1. Preclinical Evidence -- 6.2. Clinical Evidence -- 7. Conclusions -- Acknowledgments and Disclosures -- References -- Chapter Five: The Role of the Melanocortin System in Drug and Alcohol Abuse -- 1. Introduction -- 2. Melanocortin Receptors