Front Cover -- Peptidomics of Cancer-Derived Enzyme Products -- Copyright -- Contents -- Contributors -- Preface -- Overview -- 1. Molecular Changes in Cancer -- 2. Peptidomes and Advance in Mass Spectrometry -- 3. Nanotechnology and Nanodevices -- 4. Future Perspective -- Chapter One: Circulating Peptidome and Tumor-Resident Proteolysis -- 1. Introduction -- 1.1. Intracellular Proteases -- 1.1.1. Caspases (Cysteine Protease) -- 1.1.2. Deubiquitinases (Cysteine and Zinc Proteases) -- 1.1.3. Autophagins (Cysteine Proteases) -- 1.2. Extracellular Proteases

1.2.1. Matrix Metalloproteinases1.2.2. Cysteine Cathepsins -- 1.2.3. Kallikreins -- 2. Organism and Cancer Degradomes -- 3. Tumor-Associated Peptidomics -- 4. Tumor Proteases Relative Peptide in Cancer Detection -- 5. Conclusion -- References -- Chapter Two: The Peptidome Comes of Age: Mass Spectrometry-Based Characterization of the Circulating Cancer Peptidome -- 1. Introduction -- 2. Biological Role of Peptides -- 3. Peptidomics: The Study of Physiological Peptides -- 4. Mass Spectrometry and Top/Middle-Down Proteomics

4.1. Mass Spectrometry Technology Developments for Peptidomics4.2. Top-Top-Down or Native Mass Spectrometry -- 4.3. Top-Down-Based Mass Spectrometric Imaging -- 5. Strategies to Enrich the Peptidome -- 5.1. Selective Precipitation -- 5.2. Centrifugal Ultrafiltration -- 5.3. Capillary Ultrafiltration -- 5.4. Surface-Derivatised Magnetic Beads -- 5.5. Nanoporous Substrates -- 6. Application of Peptidomics in Cancer Biomarker Discovery -- 6.1. Role of Peptidomics as in Cancer Biomarker Discovery -- 6.2. Peptidomics and Cancer Diagnosis

6.3. Plasma Protein/Peptide Profiling6.4. The Plasma Interactome -- 6.5. Endoproteolytic Cleavage -- 6.6. Exoproteolytic Cleavage -- 7. Data Processing and Informatics for Peptidome Analyses -- 7.1. Sequence Databases -- 7.2. Data Analyses -- 7.3. Data Repository -- 8. Emerging Technologies -- 9. Future Perspectives -- Acknowledgments -- References -- Chapter Three: Peptide Hormones as Tumor Markers in Clinical Practice -- 1. Introduction -- 2. Selected Peptide Hormones as Tumor Markers -- 2.1. Calcitonin -- 2.1.1. Biosynthesis From Prohormone

2.1.2. Clinical Significance as Tumor Marker2.2. Alpha- and Beta-hCG -- 2.2.1. Processing of hCG -- 2.2.2. Clinical Applications as Tumor Markers -- 2.3. Insulin and C-Peptide -- 2.3.1. Biosynthesis From Prohormone -- 2.3.2. Clinical Significance as Tumor Marker -- 2.4. PTHrp -- 2.4.1. Biosynthesis From Prohormone -- 2.4.2. Clinical Significance as Tumor Marker -- 2.5. Gastrin -- 2.5.1. Biosynthesis From Prohormone -- 2.5.2. Clinical Significance as Tumor Marker -- 2.6. VIP -- 2.6.1. Biosynthesis From Prohormone