Intro; Title page; Table of Contents; Copyright page; Contributors; Preface and Ganglioside Nomenclature; Preface; Ganglioside Nomenclature; Chapter One: Ganglioside Metabolism in Health and Disease; Abstract; 1. Introduction; 2. Anabolism of gangliosides; 3. Anabolism and disease; 4. Catabolism; 5. Catabolism of gangliosides; 6. Regulation of ganglioside catabolism; Acknowledgment; Abbreviations; Chapter Two: Congenital Disorders of Ganglioside Biosynthesis; Abstract; 1. Introduction; 2. GM2/GD2 synthase deficiencies (B4GALNT1 mutations) in human disease.

3. GM3 synthase deficiencies (ST3GAL5 mutations) in human disease4. Perspectives; Chapter Three: Gangliosides in Membrane Organization; Abstract; 1. Chemical structure of gangliosides; 2. Physicochemical properties of gangliosides: a driving force for membrane organization; 3. Local modulation of membrane ganglioside composition: a mechanism for the fine tuning of membrane lateral organization; 4. Changes of ganglioside-driven membrane organization as a pathogenetic mechanism; 5. Conclusions; Chapter Four: Biological and Pathological Roles of Ganglioside Sialidases; Abstract; 1. Introduction.

2. Biological roles of ganglioside sialidases3. Pathological roles of ganglioside sialidases; 4. Concluding remarks; Chapter Five: Biology of GM3 Ganglioside; Abstract; 1. Introduction; 2. Molecular biology of GM3S/ST3GAL5; 3. Insulin resistance in adipocytes and macrophages; 4. Leptin signaling and resistance in hypothalamus; 5. T-cell immunity and immune disorders; 6. GM3S deficiency and hearing loss; 7. Conclusions and future directions; Acknowledgments; Chapter Six: Gangliosides in Cancer Cell Signaling; Abstract; Abbreviations; 1. Introduction; 2. Ganglioside biosynthesis and degradation.

3. Cellular and molecular biology of GTs and sialidases4. Regulation of cell signaling by gangliosides in cancer cells; 5. Gangliosides and apoptosis signaling; 6. Biological roles and relevance of sialidases in cancer; 7. Conclusions; Acknowledgments; Chapter Seven: Gangliosides in Diabetic Wound Healing; Abstract; 1. Introduction; 2. GM3 mediates insulin resistance in diabetes; 3. GM3 is a driver of impaired wound healing in type 2 diabetic mice; 4. The insulin/IGF1 signaling axis in diabetes and diabetic wounds; 5. Gangliosides regulate IGF1R signaling axis in cultured KCs; 6. Conclusions.