Front Cover -- Advances in Genetics -- ADVANCES IN GENETICS, VOLUME 101 -- Darwin's Pangenesis and Its Rediscovery Part A -- Copyright -- Contents -- AUTHOR'S BIOGRAPHY -- PREFACE -- One -- Darwin's Pangenesis: A Theory of Everything? -- 1. THE ORIGIN OF SPECIES: AN INCOMPLETE EXPLANATION OF EVOLUTION -- 2. THE VARIATION OF ANIMALS AND PLANTS UNDER DOMESTICATION: DARWIN'S LEGACY TO GENETICS -- 2.1 The Variation: Darwin's "Big Book" -- 2.2 The Variation: A Valuable Storehouse of Facts and Observations -- 2.3 Darwin: A Pioneer of Genetics? -- 3. PANGENESIS AS AN EXPANDED CELL THEORY -- 3.1 Cell Theory Before Darwin -- 3.2 Pangenesis as the Third Version of the Cell Theory -- 3.3 Rethinking the Cell Theory -- 4. PANGENESIS AS A UNIFIED THEORY OF HEREDITY, VARIATION, DEVELOPMENT AND REPRODUCTION -- 4.1 Genetical Theory Before Darwin -- 4.2 The Facts That Pangenesis Was Designed to Explain -- 4.3 Darwin's Confidence in Pangenesis -- 5. DARWIN'S PANGENESIS: A SLEEPING BEAUTY? -- REFERENCES -- Two -- The Criticisms of Pangenesis: The Years of Controversy -- 1. DARWIN'S PANGENESIS: A BRILLIANT BLUNDER? -- 2. GALTON'S FAILURE TO TEST PANGENESIS BY BLOOD TRANSFUSION -- 2.1 Galton's Blood Transfusion Experiment -- 2.2 Darwin's Defence in Nature and Galton's Response -- 2.3 What if Galton Had Studied Poultry? -- 2.4 Was Galton's Conclusion Reliable? -- 3. THE PROBLEM OF THE INHERITANCE OF ACQUIRED CHARACTERS -- 3.1 Weismann's Experiment on Docking the Tails of Mice -- 3.2 Does Weismann's Experiment Constitute a Denial of Pangenesis? -- 3.3 Kammerer's Midwife Toad -- 3.4 Lysenko's Converted Wheat -- 4. OTHER DOUBTFUL PHENOMENA THAT PANGENESIS SUPPOSEDLY EXPLAINS -- 4.1 Graft Hybridization -- 4.2 Telegony -- 4.3 Xenia -- 5. LACK OF DIRECT EVIDENCE FOR THE EXISTENCE OF GEMMULES -- REFERENCES -- Three -- The Influence of Darwin's Pangenesis on Later Theories.

1. GALTON'S "A THEORY OF HEREDITY" AND "NATURAL INHERITANCE" -- 1.1 Darwin's Influence on Galton -- 1.2 Galton's "A Theory of Heredity" -- 1.3 Galton's "Natural Inheritance" -- 2. WEISMANN'S THEORY OF "CONTINUITY OF THE GERM-PLASM" -- 2.1 Weismann's Comments on Darwin's Pangenesis -- 2.2 Weismann's Theory of "Continuity of the Germ-Plasm" -- 2.3 A Comparison of Darwin's and Weismann's Theory -- 3. DE VRIES' "INTRACELLULAR PANGENESIS" AND "THE MUTATION THEORY" -- 3.1 Darwin's Influence on de Vries -- 3.2 de Vries' "Intracellular Pangenesis" -- 3.3 de Vries' "The Mutation Theory" -- 4. BROOKS' "THE LAW OF HEREDITY" -- 5. ROSS'S GRAFT THEORY OF DISEASES -- 6. PERIGENESIS, SYMBIOGENESIS AND OTHER THEORIES -- 7. A COMPARISON BETWEEN DARWIN'S PANGENESIS AND OTHER THEORIES -- REFERENCES -- Four -- In Search of Darwin's Imaginary Gemmules -- 1. THE TERM "GENE" EVOLVED FROM DARWIN'S "GEMMULE" -- 1.1 Darwin's Gemmule -- 1.2 de Vries' Pangen -- 1.3 Johannsen's Gene -- 2. MORGAN'S THEORY OF THE GENE AND MCCLINTOCK'S JUMPING GENES -- 2.1 Morgan's Theory of the Gene -- 2.2 McClintock's Discovery of Jumping Genes -- 2.3 A Comparison of Darwin's Gemmule With Different Gene Concepts -- 3. THE DISCOVERY OF CIRCULATING NUCLEIC ACIDS -- 3.1 Miescher's Discovery of Nucleic Acids -- 3.2 Mandel and Metais' Discovery of Circulating Nucleic Acids -- 3.3 Mobile RNAs -- 4. THE DISCOVERY OF PRIONS -- 5. THE DISCOVERY OF EXTRACELLULAR VESICLES -- REFERENCES -- Five -- Darwin's Pangenesis and the Lamarckian Inheritance of Acquired Characters -- 1. DARWIN'S BELIEF IN THE INHERITANCE OF ACQUIRED CHARACTERS -- 2. GROWING EVIDENCE FOR THE INHERITANCE OF ACQUIRED CHARACTERS -- 2.1 Inheritance of Food and Fertilizer Effects -- 2.2 Inheritance of Acquired Habit -- 2.3 Inheritance of Acquired Immunity -- 2.4 Inheritance of Characters Induced by Temperature and Light.

2.5 Inheritance of Characters Induced by Chemicals and Drugs -- 2.6 Inheritance of Age Effects -- 2.7 Early Stages of Development: Critical Periods in Acquired Inheritance? -- 3. DARWIN'S PANGENESIS AND ENVIRONMENTALLY INDUCED DNA CHANGES -- 4. DARWIN'S PANGENESIS AND RNA-MEDIATED INHERITANCE -- 5. DARWIN'S PANGENESIS AND HORIZONTAL GENE TRANSFER -- REFERENCES -- Back Cover.