Front Cover; Advances in Cancer Research; Advances in Cancer Research:Sphingolipids in Cancer; Contents; CONTRIBUTORS; FOREWORD; PREFACE; One -- Mechanisms of Ceramide-Dependent Cancer Cell Death; 1. INTRODUCTION; 2. SPHINGOLIPID METABOLISM AND CANCER; 2.1 Structure and Metabolism of Sphingolipids; 2.2 Enzymes of Ceramide Metabolism and Cancer; 2.2.1 Serine Palmitoyltransferase; 2.2.2 Ceramide Synthases 1-6; 2.2.3 Dihydroceramide Desaturase (DES or DEGS1); 2.2.4 Sphingomyelinases; 2.2.5 Sphingomyelin Synthases and Ceramide Transporter; 2.2.6 Ceramide Kinase; 2.2.7 Glucosylceramide Synthase

2.2.8 Ceramidases3. CERAMIDE IN CANCER CELL DEATH; 3.1 Ceramide and Apoptosis; 3.2 Ceramide and Necroptosis; 3.3 Ceramide and Lethal Autophagy or Mitophagy; 3.4 Ceramide and Endoplasmic Reticulum Stress; 3.5 Ceramide and Cell Cycle Arrest; 4. SPHINGOLIPID METABOLISM AND ANTICANCER THERAPY; 4.1 Ceramide Generation in the Induction of Chemotherapy/Radiation-Mediated Tumor Suppression; 4.2 Ceramide Metabolism in Tumor Immunology and Immunotherapy; 4.2.1 Targeting Sphingolipid Metabolism and Signaling for Cancer Therapy; 5. DISCUSSION; ACKNOWLEDGMENTS; REFERENCES; FURTHER READING

Two -- Sphingolipids as Regulators of Autophagy and Endocytic Trafficking1. INTRODUCTION; 2. THE MOLECULAR MACHINERY OF AUTOPHAGY AND REGULATION BY SPHINGOLIPIDS; 2.1 Autophagy Initiation: the Unc-51-Like Kinase Complex; 2.1.1 Sphingolipids in Autophagy Initiation; 2.2 Phagophore Nucleation: the Phosphatidylinositol 3-Kinase Complex; 2.2.1 Sphingolipids in Phagophore Nucleation; 2.3 Phagophore Elongation: LC3 Lipidation; 2.3.1 Sphingolipid-Mediated Regulation of LC3 Lipidation; 2.4 Phagophore Elongation: Membrane Delivery and Autophagic Cargo

2.4.1 Sphingolipid Regulation of Membrane Delivery and Autophagic Cargo2.5 Phagophore Closure; 2.6 Autophagosome-Lysosome Fusion; 2.6.1 Sphingolipids in Autophagosome Maturation; 3. SPHINGOLIPID-MEDIATED AUTOPHAGY IN CANCER: DR. JEKYLL AND MR. HYDE; 3.1 Dr. Jekyll: A Driver of Cancer Cell Survival; 3.2 Mr. Hyde: Inducer of Autophagy-Dependent Cancer Cell Death; 3.2.1 Lethal Mitophagy; 3.2.2 Autophagic Cell Death by Noncanonical Autophagy; 3.2.3 Autophagy-Dependent Lysosomal Membrane Permeabilization; 3.2.4 Autophagy-Dependent Noncanonical Caspase-8 Activation

3.2.5 Autophagy-Dependent Apoptosis via the Calpain-Mediated Cleavage of ATG54. CONCLUSION AND FUTURE DIRECTIONS; REFERENCES; Three -- Role and Function of Sphingomyelin Biosynthesis in the Development of Cancer; 1. STRUCTURE AND INTRACELLULAR DISTRIBUTION OF SPHINGOMYELIN; 2. THE SPHINGOMYELIN SYNTHASE ENZYMES; 3. FUNCTIONS OF THE LIPIDS REGULATED BY THE SPHINGOMYELIN SYNTHASE REACTION; 3.1 Sphingomyelin; 3.1.1 Regulation of Lipid Microdomains in the Outer Leaflet of the Plasma Membrane and Impact on Receptor-Mediated Signaling