Front Cover; International Review of Cell and Molecular Biology; INTERNATIONAL REVIEW OF CELL AND MOLECULAR BIOLOGY; INTERNATIONAL REVIEW OFCELL AND MOLECULAR BIOLOGY: Mitochondria and Longevity; Contents; CONTRIBUTORS; One -- Mitochondrial Metabolism and Aging in Yeast; 1. INTRODUCTION; 2. THE TRICARBOXYLIC ACID CYCLE; 3. TRICARBOXYLIC ACID CYCLE DYSFUNCTIONS AND AGING; 4. IMPAIRED MITOCHONDRIAL PYRUVATE/ACETYL-COA METABOLISM AND AGING; 5. MITOCHONDRIAL METABOLISM OF BRANCHED-CHAIN AMINO ACIDS AND AGING; 6. THE OXIDATIVE PHOSPHORYLATION

7. RESPIRATION, ROS PRODUCTION AND AGING: A COMPLEX INTERPLAY7.1 Complex I; 7.2 Complex II; 7.3 Complex III; 7.4 Complex IV; 7.5 F1FO ATPase; 8. ROLE OF NAD+ METABOLISM IN MITOCHONDRIAL FUNCTIONALITY; 9. NAD+ METABOLISM AND AGING; 10. NAD+ IS A KEY MODULATOR OF PATHWAYS INVOLVED IN THE AGING PROCESS; 11. CONCLUSIONS; ACKNOWLEDGMENTS; REFERENCES; Two -- Mitohormesis, an Antiaging Paradigm; 1. INTRODUCTION; 2. MITONUCLEAR COMMUNICATION; 3. MITOHORMESIS SIGNALING; 3.1 Reactive Oxygen Species; 3.2 Mitochondrial Ions and Metabolites; 3.3 Proteotoxic Signals

3.4 Mitochondria-Cytosol Stress Responses3.4.1 Translational Stress Response; 3.4.2 Post-translational Stress Responses; 3.5 Mitokines; 4. MITOHORMESIS AND LIFESPAN; 5. MITOHORMESIS AND HEALTHSPAN; 6. CONCLUDING REMARKS AND FUTURE OUTLOOK; REFERENCES; Three -- Coordinating Mitochondrial Biology Through the Stress-Responsive Regulation of Mitochondrial Proteases; 1. INTRODUCTION; 1.1 Organization and Activity of the Mitochondrial Proteolytic Network; 1.1.1 Processing Peptidases Facilitate Establishment of the Mitochondrial Proteome

1.1.2 Mitochondrial Quality Control Proteases Regulate the Integrity and Function of the Mitochondrial Proteome1.1.3 Oligopeptidases Degrade Polypeptides Within Mitochondria; 1.2 Mitochondrial Proteases Are Key Regulators of Organellar Quality Control; 1.2.1 Mitochondrial Morphology Is Regulated by the Activity of Mitochondrial Proteases; 1.2.2 Proteolytic Control of Mitophagy; 1.3 Mitochondrial Proteases Link Mitochondrial Proteostasis to Apoptotic Signaling; 1.4 Stress-Responsive Regulation of the Mitochondrial Proteolytic Network

1.4.1 Mitochondrial Unfolded Protein Response-Dependent Regulation of Mitochondrial Proteostasis1.4.2 The Integrated Stress Response Coordinates Mitochondrial Proteostasis in Response to Diverse Insults; 1.4.3 LON Is Also Transcriptionally Regulated by Other Stress-Responsive Signaling Pathways; 1.4.4 Posttranslational Regulation of Mitochondrial Proteolytic Activity; 1.5 Altered Mitochondrial Protease Activity in Aging and Disease; 1.5.1 Mutations in Mitochondrial Proteases Are Genetically Linked to Diverse Neurodegenerative Disorders