Intro; Title page; Table of Contents; Copyright; Contributors; Preface; Chapter One: Analysis of Protein Interactions by Surface Plasmon Resonance; Abstract; 1 Introduction; 2 Methodology; 3 Applications; 4 Future Directions; Acknowledgment; Chapter Two: Using TR-FRET to Investigate Protein a#x80;#x93;Protein Interactions: A Case Study of PXR-Coregulator Interaction; Abstract; 1 Introduction; 2 Materials; 3 Methods; 4 Results and Discussion; 5 Conclusions; Acknowledgments; Chapter Three: Protein a#x80;#x93;Protein Interaction Modulators for Epigenetic Therapies; Abstract; 1 Introduction

2 PPI Modulators in Epigenetic Drug Discovery3 Peptides in Drug Discovery; 4 Peptides as Modulators of Epigenetic-Related PPIs; 5 Conclusions and Perspectives; Acknowledgments; Chapter Four: Intrinsic Disorder, Protein a#x80;#x93;Protein Interactions, and Disease; Abstract; 1 (Almost) Everything You Learned About Proteins From the Textbooks Is Wrong (or At Least Incomplete); 2 IDPs: Interaction Specialists; 3 IDPs and Disorder-Based Interactions in Human Diseases; 4 Concluding Remarks; Chapter Five: Targeting Protein a#x80;#x93;Protein Interactions in the Ubiquitin a#x80;#x93;Proteasome Pathway; Abstract

1 Introduction2 Targeting the Polyubiquitination Cascade; 3 Targeting the Proteasome; 4 Conclusion; Acknowledgment; Chapter Six: Probing the Protein a#x80;#x93;Protein Interaction Network of Proteins Causing Maturity Onset Diabetes of the Young; Abstract; 1 Introduction; 2 Materials and Methods; 3 Results; 4 Overall Protein Interaction of the Proteins; 5 TFs of the MODY Causing Proteins; 6 Discussion; 7 Conclusion; Acknowledgment; Chapter Seven: Structural Prediction of Protein a#x80;#x93;Protein Interactions by Docking: Application to Biomedical Problems; Abstract

1 Importance of Protein a#x80;#x93;Protein Interactions in Cell2 Protein a#x80;#x93;Protein Interactions and Human Disease; 3 Structural Approach to Protein a#x80;#x93;Protein Interactions; 4 Computational Modeling of Protein a#x80;#x93;Protein Interactions; 5 Application of Computational Docking to Biomedicine; Acknowledgments; Chapter Eight: Computational Resources for Predicting Protein a#x80;#x93;Protein Interactions; Abstract; 1 Introduction; 2 Prediction of PPIs; 3 Computational Tools for PPIN Visualization; 4 PPI Databases; 5 Role of Molecular Dynamics in Predicting PPIs; 6 Types of Interactions Between Proteins; 7 Discussion