Part I: Computational Biomechanics Frameworks and Models for Computer-Assisted Therapy and Understanding of Disease Mechanisms -- Chapter 1. Automatic framework for patient-specific biomechanical computations of organ deformation -- Chapter 2. Computer simulation of the resection induced brain shift; Preliminary results -- Chapter 3. Mandibular teeth movement variations in tipping scenario: A finite element study on several patients -- Chapter 4. Computational biomechanics model for analysis of cervical spinal cord deformations under whiplash-type loading -- Part II: Biomechanical tissue characterisation, determining organ geometry, and organ deformation measurements -- Chapter 5. An unsupervised learning based deformable registration network for 4D-CT: Analysis and application -- Chapter 6. 3D reconstruction of patient-specific carotid artery geometry using clinical ultrasound imaging -- Chapter 7. Feasibility of using Freehand Ultrasound imaging to measure anatomical features of the Ischial Tuberosity to improve the prevention of seating-related pressure injury: US-based versus EOS-based assessment -- Chapter 8. Characterising the soft tissue mechanical properties of the lower limb of a below-knee amputee: a review -- Chapter 9. 3D Brain Deformation in cadaveric specimens compared to healthy volunteers under non-injurious loading conditions.