Physiological Notes -- Intrinsic (or auto-) PEEP during controlled mechanical ventilation -- Intrinsic (or auto-) positive end-expiratory pressure during spontaneous or assisted ventilation -- Work of breathing -- Interpretation of airway pressure waveforms -- Dead space -- Alveolar ventilation and pulmonary blood flow: the concept -- Mechanisms of hypoxemia -- Pulse oximetry -- Effects of body temperature on blood gases -- Venous oximetry -- Relation between PaO2/FIO2 ratio and FIO2: a mathematical description -- Pulmonary vascular resistance -- Pulmonary artery occlusion pressure -- Clinical significance of pulmonary artery occlusion pressure -- Pulmonary capillary pressure -- Ventricular interdependence: how does it impact on hemodynamic evaluation in clinical practice? -- Cyclic changes in arterial pressure during mechanical ventilation -- Lactic acidosis -- Defining acute renal failure: physiological principles -- Hypotension during intermittent hemodialysis: new insights into an old problem -- Intracranial pressure -- Intracranial pressure -- Physiological Reviews -- Fluid responsiveness in mechanically ventilated patients: a review of indices used in intensive care -- Different techniques to measure intra-abdominal pressure (IAP): time for a critical re-appraisal -- Tissue capnometry: does the answer lie under the tongue? -- Noninvasive monitoring of peripheral perfusion -- Ultrasonographic examination of the venae cavae -- Sleep in the intensive care unit -- Magnesium in critical illness: metabolism, assessment, and treatment -- Pulmonary endothelium in acute lung injury: from basic science to the critically ill -- Pulmonary and cardiac sequelae of subarachnoid haemorrhage: time for active management? -- Permissive hypercapnia - role in protective lung ventilatory strategies -- Right ventricular function and positive pressure ventilation in clinical practice: from hemodynamic subsets to respirator settings -- Acute right ventricular failure-from pathophysiology to new treatments -- Red blood cell rheology in sepsis -- Stress-hyperglycemia, insulin and immunomodulation in sepsis -- Hypothalamic-pituitary dysfunction in critically ill patients with traumatic and nontraumatic brain injury -- Matching total body oxygen consumption and delivery: a crucial objective? -- Normalizing physiological variables in acute illness: five reasons for caution -- Seminal Studies in Intensive Care -- Manipulating afterload for the treatment of acute heart failure -- Nosocomial pneumonia -- The introduction of positive endexpiratory pressure into mechanical ventilation: a retrospective -- Elastic pressure-volume curves in acute lung injury and acute respiratory distress syndrome -- The concept of "baby lung" -- The effects of anesthesia and muscle paralysis on the respiratory system -- Diaphragmatic fatigue during sepsis and septic shock -- The use of severity scores in the intensive care unit -- Oxygen transport-the oxygen delivery controversy -- Organ dysfunction during sepsis -- Ventilator-induced lung injury: from the bench to the bedside -- Remembrance of weaning past: the seminal papers.