Journal of Biomedical Semantics addresses issues of semantic enrichment and semantic processing in the biomedical and clinical domain. The scope of the journal covers two main areas: Infrastructure for biomedical semantics: focusing on semantic resources and repositories, ontology design, meta-data standards and management, resource description, knowledge representation and semantic frameworks, the Biomedical Semantic Web, and semantic interoperability. Semantic mining, annotation, and analysis: focusing on approaches and applications of semantic resources; and tools for investigation, reasoning, prediction, artificial intelligence modelling, and discoveries in biomedicine.